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If you enjoy the sensation of being utterly pampered on vacation, find it here in Davao? your tropical holiday destination.
Davao has spas, health and wellness facilities that cater to a wide range of market. Thus, no visit is come without a soothing massage and the luxury of being pampered. Some may view this as a mere indulgence, yet is vital for one?s health and well being. Whether it?s a bit of reflexology you?re looking for or a complete shiatsu or aromatherapy massage, they?re certainly the catchphrase of the day.
The edge of Davao is that whatever your budget, there is something affordable for everyone. Certainly you get what you pay for, but you can quite literally get an incredible 30 minutes foot massage for as low as PhP150.00!
A special treatment in the hands of a Davao masseuse/theraphist with their healing hands, combined with their warmth and care will leave you feeling on top of the world. Spa goers get a wide range of spa treatment and products to balance the body, comfort the mind, and feed the spirit.
Faces of Davao will be featuring health and wellness enclaves around the city and neighboring places. For this month, we?re happy to take advantage of the special treatment from Pacific Spa.
Pacific Spa offers exquisite pampering with several indulgent body and beauty treatments. It is a one-stop-shop that never ceases until you feel healthy and beautiful inside and out, from head to toe, with its skin care and dermatological treatments and relaxation therapies. Try their Seashell massage, Five Nectar Bath, Herbal Aroma Therapeutic Soak, waxing, Tropical Derm Facials and many others for a truly pampering experience.
You should check ?em out! Treat yourself with a budget friendly experience. They are conveniently located at Claro M. Recto Street, Davao City beside Marco Polo Hotel fronting Aldevinco back of Miami Foods. There?s a street in between BDO and Miami Foods which is the only road to get to the spa.
For more details, visit www.pacificdavao.com or call +(63) 82-300-8880 or +(63) 923-300-8880 .
Writer: Neo Richard Diongson Photographer: Lyndle Kevin Sorronda Stylist: Anne Suan Model: JR Estudillo and Lorraine Faye Emplamado (Top 100 Faces of Davao 2012 April Circle of 12 Finalists) Location: Pacific Spa ? Claveria, Davao City
Dorm room essentials like task lighting, storage solutions and organizers help create a comfortable and efficient workspace. Most college dorms offer a study desk and chair to each to their residents. If you prefer to create an independent workspace, it is important to give careful thought to its specifications. Keep the shape and size of your dorm room in mind when deciding on a desk.
Corner that Workspace Make use of an unused nook with a strategically placed corner desk. These modular desks are designed to fit into a corner, and are great dorm accessories, especially for small single rooms. A collapsible desk is another great fixture. The desk designs often feature a pullout workspace that can be folded onto the desk when you are not working. These great space-saving dorm room essentials also contain electrical outlets for your computer, laptop, printer and other essential electronic devices.
Solo Storage Space for All Your Work Storage for your textbooks, notes and papers is critical for a good workspace. Modify the existing study desk by adding a desk hutch for all your study material. An alternative is to choose independent storage units. Storage bins made of green materials like rattan or recycled papers are a stylish and environment-friendly option. Papers that are not immediately needed can go into canvas storage bins, which can then be stored at the back of the closet or under the bed.
Light Up Right Lighting is another key consideration when deciding on dorm accessories. Choose a good quality task lamp for late night study sessions. The special hinged design allows you to bend or twist these table lamps in almost any direction. This makes it easy to focus the light on the precise spot where you most need it. These practical and stylish dorm room essentials come in several different colors.
Multipurpose task light organizers are cool alternatives to regular task lamps. Opt for these fun and useful desk lamps for a study light that doubles as a handy desktop organizer. Within the organizer section, there are usually deep cup areas for your stationery and smaller trays that can hold paper clips or rubber bands. Choose eco-friendly CFL light bulbs for your table lamps. These tend to be long-lasting and energy-efficient in comparison to incandescent or halogen bulbs.
Start your search today to find the coolest dorm accessories for your study area.
Author Profile: Steffy Roy is a certified interior designer and runs her own interior decoration consultancy. Steffy especially loves decorating a home in wooden furniture and believes that nothing gives a home as warm and cozy a touch as all-wood furniture and decor. Steffy loves reading up on new design ideas, and has a special interest in space saving techniques. Here she writes about dorm room essentials and dorm accessories.
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Ethiopia has passed a draconian new law criminalizing the use of Voice over Internet Protocol services such as Skype or Google Talk. People who violate the ban will find themselves facing 10-to-15 years in prison. The government has cited national security as a reason.
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NEW YORK ? Facebook Inc.?s bungled stock-market debut made it clear that big money still rules Wall Street. But this time, the small money got a look at how Wall Street really works ? and that could spell trouble for the financial industry.
Millions of small investors have trimmed their investments in stocks after seeing their 401(k) accounts pulverized by the market plunge in 2008-09. The May 2010 flash crash ? in which $1 trillion briefly vanished from the stock market ? served as another flashing yellow caution sign.
Facebook, with its worldwide popularity, was seen as a chance to rekindle popular interest in stocks when its shares began trading publicly last week.
Then the stock flopped. Investor enthusiasm was expected to be red-hot, but many backed away amid trading glitches on the Nasdaq, widespread news reports of insider selling and nagging questions about the company?s future prospects.
In the aftermath, it also became clear that big investors and wealthy clients had been warned the company?s financial outlook had weakened. Instead of rekindling interest in stocks, Facebook?s debut fueled long-running concerns about how the stock market works.
?This has proved the game is rigged,? said Charles Geisst, a finance professor and Wall Street historian at Manhattan College. ?There?s just too many questions about the integrity of the stock market, and I think people are starting to realize this ? individuals, at least.?
Prominent investor Mark Cuban, owner of the Dallas Mavericks basketball team, declared on his blog Wednesday that the investing public?s positive impression of the stock market had been ?torched to the ground.?
Retail investors reportedly got 25 percent of Facebook?s 421 million shares in the initial public offering. The value of that allotment has declined by more than $500 million, based on Facebook?s closing price of $33.03 a share Thursday.
Regulators and congressional investigators have begun probes into what went wrong, looking into questions over information distributed ahead of the IPO. Morgan Stanley and other underwriters warned privileged clients that their analysts had grown sour on Facebook?s revenue growth potential. They failed to telegraph the same information to retail clients and the general public.
Information affords a crucial trading edge on Wall Street. Regulators have tried to level the playing field for years.
A decade ago, regulators led by then-Attorney General Eliot Spitzer discovered widespread manipulation of Wall Street analysts? reports. He exposed a long practice on Wall Street in which analysts would write favorable research so their banks could win investment banking business.
Regulators settled their cases against 10 major firms for $1.4 billion in 2003 and put in place strict rules dividing banks? research and investment banking divisions.
Although securities law experts say it?s unclear whether Facebook?s underwriters have broken any rules, Spitzer said underwriters? selective disclosures in Facebook?s IPO may have violated laws against financial fraud.
He said underwriters? actions may violate the ?most fundamental principle, which is that an underwriter needs to be forthright, honest to the public.?
?Market theory is very simple,? Spitzer said. ?You can?t give false and misleading material information to people, where you know it?s false and you correct it only to some but not to others.?
Morgan Stanley declined to comment, but it has said its IPO procedures were ?in compliance with all applicable regulations.?
Giving well-connected firms an inside track has been one of the ways that big Wall Street firms attract and keep big clients. These clients are powerful profit drivers, and banks tend to give their best customers the best deals.
?These people give them more money in fees and commissions than others,? said Ernest Badway, a former U.S. Securities and Exchange Commission enforcement attorney who is now a white-collar defense lawyer in New York and New Jersey.
?Because of that ? they?re part of a great revenue stream ? they?re going to try to give every single advantage that they can to those particular people,? he said.
Large institutions and wealthy investors have a symbiotic relationship with Wall Street bankers. ?The retail guy is at the end of the queue,? Geisst said. ?He can?t do anybody any favors.?
In April, the SEC settled a somewhat similar case against Goldman Sachs involving precious tips to favored clients.
To generate more revenue, the giant Wall Street investment bank?s analysts and traders held ?huddles? to share market commentary and trading ideas. During morning conference calls, Goldman passed along inside information to a select group of about 180 hedge fund and investment management clients.
Goldman, which brought in $37 billion in revenue last year, paid a $22 million fine to settle the case.
SEC rules generally require public companies to disclose ?material? information to all investors once they disclose the same information to analysts and other market participants. But the rule governing fair disclosure ? known as Regulation FD ? has an exemption that allows companies to selectively disclose information while they are on ?road shows? pitching IPOs to prospective investors, said John Coffee, a Columbia Law School professor who is an expert in securities regulations.
?There should be a rule that you can?t disclose information at a road show unless you?re willing to simultaneously disclose it to retail investors,? Coffee said.
Government inquiries have only just begun, and no one involved in the process has been accused of any wrongdoing. What rule changes, if any, may result from the Facebook IPO remain to be seen. But Spitzer and others say it?s a reminder that the big boys still rule Wall Street.
?The small guy is not getting a fair shot in the market,? Spitzer said. ?That unfortunately has been true for too many years.?
Posted in Uncategorized on 05/21/2012 04:28 am by Gold
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Insulin resistance in the brain precedes and contributes to cognitive decline above and beyond other known causes of Alzheimer's disease, according to a new study by researchers from the Perelman School of Medicine at the University of Pennsylvania. Insulin is an important hormone in many bodily functions, including the health of brain cells. The team identified extensive abnormalities in the activity of two major signaling pathways for insulin and insulin-like growth factor in non-diabetic people with Alzheimer's disease. These pathways could be targeted with new or existing medicines to potentially help resensitize the brain to insulin and possibly slow down or even improve cognitive decline.
This is the first study to directly demonstrate that insulin resistance occurs in the brains of people with Alzheimer's disease. The study is now online in the Journal of Clinical Investigation.
"Our research clearly shows that the brain's ability to respond to insulin, which is important for normal brain function, is going offline at some point. Insulin in the brain not only modulates glucose uptake, but also promotes the health of brain cells ? their growth, survival, remodeling, and normal functioning. We believe that brain insulin resistance may be an important contributor to the cognitive decline associated with Alzheimer's disease," said senior author, Steven E. Arnold, MD, professor of Psychiatry and Neurology. Arnold is also the director of the Penn Memory Center, a National Institute on Aging-designated Alzheimer's Disease Core Center. "If we can prevent brain insulin resistance from occurring, or re-sensitize brain cells to insulin with any of the currently available insulin-sensitizing diabetes medicines, we may be able to slow down, prevent, or perhaps even improve cognitive decline.
The risk of developing Alzheimer's disease is increased by 50 percent in people with diabetes. Type 2 diabetes is due to insulin resistance and accounts for 90 percent of all diabetes. The defining clinical feature of Type 2 diabetes (and Type 1 "juvenile" diabetes) is hyperglycemia - high levels of sugar in the blood ? but there is no evidence that the brain in Alzheimer's is hyperglycemic. Insulin acts differently in the brain than in the rest of the body. Researchers found that insulin resistance of the brain occurs in Alzheimer's disease independent of whether someone has diabetes, by excluding people with a history of diabetes from this study.
The investigators used samples of postmortem brain tissue from non-diabetics who had died with Alzheimer's disease, stimulated the tissue with insulin, and measured how much the insulin activated various proteins in the insulin-signaling pathways. There was less insulin activation in Alzheimer's cases than in tissue from people who had died without brain disease. Other proteins linked to insulin action in the brain were abnormal in Alzheimer's disease samples. These abnormalities were highly correlated with episodic memory and other cognitive disabilities in the Alzheimer's disease patients.
In tissue from people with Alzheimer's disease and mild cognitive impairment (MCI), researchers found that changes to a protein called insulin receptor substrate-1 (IRS-1 pS636/639 and pS616) in brain cells were linked to the severity of memory impairments regardless of age, sex, diabetes history, or apolipoprotein E (APOE) gene status. Levels of IRS-1 were also significantly associated with, but not likely to affect, the presence of amyloid beta plaques and neurofibrillary tangles, the signature markers of Alzheimer's disease. This suggests that insulin resistance contributes to cognitive decline independent of the classical pathology of Alzheimer's disease.
Researchers noted that three insulin-sensitizing medicines are already approved by the FDA for treatment of diabetes. These drugs readily cross the blood-brain barrier and may have therapeutic potential to correct insulin resistance in Alzheimer's disease and MCI. "Clinical trials would need to be conducted to determine the impact the drugs have on Alzheimer's disease and MCI in non-diabetic patients," said Dr. Arnold.
###
University of Pennsylvania School of Medicine: http://www.uphs.upenn.edu/news/
Thanks to University of Pennsylvania School of Medicine for this article.
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Individuals are quite involved about their visual appeal and recognize that it is preferable to maintain a nutritious weight. Nevertheless, with all the rapidly foods and microwave foodstuff readily available rapidly these days, it is often a struggle to try to eat well and maintain suitable bodyweight. There are a plethora of diet plan ideas out there, all guaranteeing they will get those extra lbs. However, all companies are diverse, with various levels of metabolic process and fitness. Right here are some of the fad eating plans and fast summary of the highlights of the system.
The Atkins Diet program
The simple thought behind the Atkins diet regime is to eradicate carbohydrates and gradually back again into your meals. The very first cycle lasts two weeks and you have to remove almost all carbohydrates from your diet regime without having bread, no pasta, no rice! The second phase of the plan gradually reintroduce fiber-rich carbohydrates, a little at a time right up until you achieve the ideal volume of carbs essential to achieve your ideal bodyweight.
The 3rd and fourth phases require maintaining your nutritious body excess weight.
The Pritikin diet regime
The Pritikin diet program system entails ingesting an extremely reduced amount of body fat and a large volume of carbs. Lower calorie carbs are promoted with fruits, veggies and reduced calorie protein. This diet regime has been close to considering that the late seventies and given that it is nonetheless considered a feasible diet plan, you have to nonetheless develop benefits!
The South Seashore Diet regime
The South Beach front Diet regime is equivalent to the Atkins diet plan in that it has phases, the initial is a severe restriction of carbohydrates. But most foods are permitted in the South Seaside Diet plan strategy are allowed in the Atkins diet plan strategy.
The 2nd and third phases of the South Beach front diet regime are equivalent to the second phase, 3rd and fourth the Atkins diet program.
The Jenny Craig System
The Jenny Craig plan requires ingesting their meals prepackaged frozen and understand to moderate your eating behavior and the introduction of the physical exercise in terms and conditions of fat reduction. Their counselors are accessible around the clock by telephone, as well as there are online discussion teams on issues or concerns you may have. No food items are off-limitations, just try to eat modest parts of what you like. As you reduce your consumption of foods and then incorporate workout into the plan, the lbs occur off.
The macrobiotic diet
The macrobiotic diet program emphasizes eating unprocessed food items and complex carbs. The protein in your diet program from resources other than meat. This is regarded as much more a lifestyle than a diet. By ingesting the right foods, the fat happens off by natural means.
The Mediterranean diet plan
The Mediterranean diet follows the standard diet regime of the inhabitants of the Mediterranean locations of Europe. Most proteins do not come from meat that meat use is minimal. Usage of fruits, veggies, nuts, carbohydrates and entire grain with olive oil to provide all the important proteins, carbohydrates and fats to preserve you nutritious. Physical exercise is an essential component of this program and have to be dedicated on a day-to-day foundation. It is also far more of a life style of a diet system.
?It's a weekend full of some pretty good shows and some pretty bad ones too. One of the biggest bills is Young The Giant and Grouplove at The Prophet Bar. If you didn't already get tickets, it's sold out.
Check the print section for previews of Pinkish Black and Nervous Curtains at Lola's and Ed Schrader's Music Beat at Queen City Hall. The David Mayfield Parade, Wheeler Brothers Friday, March 23, at Palladium Ballroom The David Mayfield Parade earned a place in the hearts of Avett Brothers fans while opening for them on a tour last year. The bearded bluegrass/Southern soul singer leads his band in a frequently raucous and hilarious set, which is what fans can expect at this Palladium show tonight.
Casey James Friday, March 23, at Billy Bob's Texas It's Casey James' first hometown show after the release of his new self-titled record. I heard the first single, "Let's Don't Call It a Night," on Kathie Lee and Hoda yesterday. (It comes on right before my judge shows). Unfortunately, the segment on makeovers was far more entertaining.
The Klanks Friday, March 23, at LaGrange I saw this band last week. Three dudes, not even 20. The songs were good, but their energy was fantastic. They played like there were thousands in the audience. There were 10.
Poo Live Crew Friday, March 23, at Capital Bar I can't read the name of this band without giggling.
Starship, John Parr, Survivor Friday, March 23, at Allen Event Center The members of Starship painstakingly routed their current tour to only visit cities that could very well have been built on rock and roll, which is why they're playing in Allen tonight. Next stop: Sioux City, Iowa.
The Boom Boom Box, Quiet Company Friday, March 23, at Lola's Saloon It's a rare chance for Fort Worthians to see one of Dallas' best acts. The Boom Boom Box is comprised of a mixed bag of Dallas rock alum, so you know it's good.
Air Review, The Rocketboys, Low Dark Hills Saturday, March 24, at Dada Nothing new here. Just a really decent local bill for your weekend pleasure. Air Review has left behind their Brit-pop loving ways for a more focused folk pop sound, but lengthy headlining sets like this one allow them to dip into the back catalog.
Paula Cole, Damon K. Clark Saturday, March 24, at The Kessler Theater Remember that song at the beginning of Dawson's Creek? What's the over/under on it getting played? Even if you didn't like the show much, Paula Cole has written about seven albums since, and local jazz singer Damon Clark will open the show.
"Winter Jam" Sunday, March 25, at American Airlines Center It's a massive Christian music festival featuring Skillet, a dude from Newsboys and a bunch of other, in all honesty, awful, awful bands. Local singer Kari Jobe, who has made a big impact in the Christian music world, will brighten up the bill.
CNS Rome bureau: Pope calls for patience in fight to bring freedom to communist Cuba: bit.ly/GXgFKY #CNSstoryabout 6 hours agovia twitterfeedRetweeted by 2 people
Journal of Infectious Diseases special supplement for World TB Day, March 24, 2012Public release date: 22-Mar-2012 [ | E-mail | Share ]
Contact: Alimuddin Zumla a.zumla@ucl.ac.uk 44-790-463-8375 University College London
'Tuberculosis and TB/HIV/AIDS: Unanswered Questions and Controversies' launches at World TB Day Conference 'Tuberculosis -- Local and Global'
To coincide with World TB day (24th March), The Journal of Infectious Diseases (JID) publishes a special supplement: 'TUBERCULOSIS and TB/HIV/AIDS: Unanswered Questions and Controversies', guest edited by Professor Alimuddin 'Ali' Zumla (Division of Infection and Immunity, UCL) and Dr. Marco Schito (Henry M. Jackson Foundation for the Advancement of Military Medicine*).
The articles from the JID supplement will be presented, along with local tuberculosis research performed at UCL and the Royal Free Hospital, at a World TB Day Conference 'Tuberculosis: Local and Global'. The event will be hosted by UCL at the Royal Free Hospital in London on Friday March 23rd.
Worldwide, tuberculosis (TB) remains one of the most important causes of death from an infectious disease. TB and TB/HIV co-disease caused an estimated 1.4 million deaths in 2010 and there were 8.8 million incident cases of TB, with the highest rates occurring in sub-Saharan Africa and the largest number of cases in Asia. Sub-Saharan Africa continues to be disproportionately affected by the dual epidemics of TB and HIV. Moreover, the number-one cause of death for HIV-infected patients in sub-Saharan Africa is TB.
While recent TB control efforts have been substantial and progress in the development of new diagnostics, drugs and vaccines has accelerated, the implementation of coordinated TB/HIV treatment and prevention activities remains challenging. Despite nearly 20 years of World Health Organisation (WHO)-directed and coordinated activity, and 12 years of multidrug-resistant (MDR) tuberculosisspecific activity, "the response to the drug-resistant tuberculosis epidemic seems to be ineffectual, with projected rapid increase in the global incidence of Multi-drug resistant tuberculosis (MDR-TB)," said Professor Zumla. "It (MDR TB) continues to spread and now poses a major threat to TB control - recent reports of highly drug resistant TB from Iran and Bombay are worrisome," he continued.
According to the supplement's accompanying editorial, the main obstacle hindering progress toward achieving TB control seems to be the lack of creative and lateral thinking with unity of purpose. Historically, some widely held assumptions, dogma, and orthodoxy have prevailed, leading to polarization of thought, varying opinions, and continued debate within the scientific, medical, funding, and various other stakeholder communities. The need for open debate and fostering of innovation is reflected by the needs surrounding all aspects of tuberculosis and HIV control strategies.
This need has never been greater, especially in the current adverse global economic climate.
The JID supplement arises from the urgent need to focus attention on core problems and secure a broad spectrum of opinion from TB and HIV/AIDS experts from various geographical backgrounds. It comprises 23 articles written by 164 authors from all over the world.
This special volume critically highlights current controversies and unanswered questions in TB and TB/HIV issues affecting adults and children, and provides insights into newer and enhanced approaches to achieving the Millennium Development Goals for TB control. Specifically, the volume covers operational issues, challenges, and priority needs relating to a broad range of diagnostic, management, prevention, surveillance and related research issues. The array of priorities spans development, evaluation, and implementation of new drugs, diagnostics, and vaccines.
"Political commitment, regulatory cohesiveness, donor investments, and increased coordination among all stakeholders is necessary to make progress," says Professor Ali Zumla. "This includes upgrading of laboratory services for early and accurate diagnosis, development and validation of better diagnostic testing algorithms, effective treatment at points of care, and improved surveillance.
"This supplement also underlines preventable factors, such as crowded living conditions and under-nutrition that continue to make communities vulnerable to disease," continues Professor Zumla. "The influence of non-communicable diseases, such as smoking-related lung disease, diet-related diabetes mellitus, malnutrition, as well as alcohol and drug abuse, highlight the need for a multi-disciplinary approach in tackling both TB and HIV."
Despite increased funding for TB, several articles point to a serious shortfall which continues to persist. The financial difficulties faced by the Global Fund place recent gains in TB control and the numbers of HIV-infected persons on life-saving treatment at serious risk in many donor-reliant countries. The global fight against TB and HIV requires perseverance, assertiveness, and innovation, and clarity of intent well beyond current efforts. All authors in the supplement call on governmental, civil society, non-governmental groups, donors, and funders to work collectively to assist in global control of TB and, ultimately, its elimination.
###
Note to editors:
Contacts for press:
Professor Alimuddin Zumla, University College London Medical School, London United Kingdom
Telephone +44 (0) 7904638375
Email: a.zumla@ucl.ac.uk
Dr. Marco Schito, Henry M. Jackson Foundation for the Advancement of Military Medicine
Division of AIDS, NIAID, NIH, DHHS, Bethesda, Maryland, USA.
Telephone: +1-301-594-5374 Cell: +1(240) 421-8470
Email: schitom@niaid.nih.gov
'Tuberculosis: Local and Global' conference website and full programme of speakers: http://www.ucl.ac.uk/global-health/project-pages/symposia/tb-local-global
For full JID Supplement: see: Journal of Infectious Diseases website: http://jid.oxfordjournals.org/ after March 23rd.
Launch of the volume at World TB Day symposium:
The volume will be launched at a World TB Day symposium being held by UCL at the Royal Free Hospital campus on Friday March 23rd, 2012 (the day before world TB Day, March 24th 2012). The symposium will include presentations from the lead authors of the articles in this volume. A programme of the event is detailed below. The symposium has been organised by Dr Tim Mchugh, Dr Marc Lipman and Professor Ali Zumla.
Acknowledgements:
This JID supplement project has been funded in part with federal funds from the National Institute of Allergies and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, (contract HHSN272200800014C). Professor Ali Zumla receives support from EuropeAID, Belgium; European and Developing Countries Clinical Trials Partnership (EDCTP),Netherlands; UK Medical Research Council (MRC); and UBS OptimusFoundation, Switzerland, University College London Hospitals Comprehensive Biomedical Research Centre (UCLH-CBRC) and the UCL Hospitals National Health Service (NHS) Foundation Trust.
*Dr. Marco Schito's full affiliation is the Henry M. Jackson Foundation for the Advancement of Military Medicine [HJF], working under contract to the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, USA.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Journal of Infectious Diseases special supplement for World TB Day, March 24, 2012Public release date: 22-Mar-2012 [ | E-mail | Share ]
Contact: Alimuddin Zumla a.zumla@ucl.ac.uk 44-790-463-8375 University College London
'Tuberculosis and TB/HIV/AIDS: Unanswered Questions and Controversies' launches at World TB Day Conference 'Tuberculosis -- Local and Global'
To coincide with World TB day (24th March), The Journal of Infectious Diseases (JID) publishes a special supplement: 'TUBERCULOSIS and TB/HIV/AIDS: Unanswered Questions and Controversies', guest edited by Professor Alimuddin 'Ali' Zumla (Division of Infection and Immunity, UCL) and Dr. Marco Schito (Henry M. Jackson Foundation for the Advancement of Military Medicine*).
The articles from the JID supplement will be presented, along with local tuberculosis research performed at UCL and the Royal Free Hospital, at a World TB Day Conference 'Tuberculosis: Local and Global'. The event will be hosted by UCL at the Royal Free Hospital in London on Friday March 23rd.
Worldwide, tuberculosis (TB) remains one of the most important causes of death from an infectious disease. TB and TB/HIV co-disease caused an estimated 1.4 million deaths in 2010 and there were 8.8 million incident cases of TB, with the highest rates occurring in sub-Saharan Africa and the largest number of cases in Asia. Sub-Saharan Africa continues to be disproportionately affected by the dual epidemics of TB and HIV. Moreover, the number-one cause of death for HIV-infected patients in sub-Saharan Africa is TB.
While recent TB control efforts have been substantial and progress in the development of new diagnostics, drugs and vaccines has accelerated, the implementation of coordinated TB/HIV treatment and prevention activities remains challenging. Despite nearly 20 years of World Health Organisation (WHO)-directed and coordinated activity, and 12 years of multidrug-resistant (MDR) tuberculosisspecific activity, "the response to the drug-resistant tuberculosis epidemic seems to be ineffectual, with projected rapid increase in the global incidence of Multi-drug resistant tuberculosis (MDR-TB)," said Professor Zumla. "It (MDR TB) continues to spread and now poses a major threat to TB control - recent reports of highly drug resistant TB from Iran and Bombay are worrisome," he continued.
According to the supplement's accompanying editorial, the main obstacle hindering progress toward achieving TB control seems to be the lack of creative and lateral thinking with unity of purpose. Historically, some widely held assumptions, dogma, and orthodoxy have prevailed, leading to polarization of thought, varying opinions, and continued debate within the scientific, medical, funding, and various other stakeholder communities. The need for open debate and fostering of innovation is reflected by the needs surrounding all aspects of tuberculosis and HIV control strategies.
This need has never been greater, especially in the current adverse global economic climate.
The JID supplement arises from the urgent need to focus attention on core problems and secure a broad spectrum of opinion from TB and HIV/AIDS experts from various geographical backgrounds. It comprises 23 articles written by 164 authors from all over the world.
This special volume critically highlights current controversies and unanswered questions in TB and TB/HIV issues affecting adults and children, and provides insights into newer and enhanced approaches to achieving the Millennium Development Goals for TB control. Specifically, the volume covers operational issues, challenges, and priority needs relating to a broad range of diagnostic, management, prevention, surveillance and related research issues. The array of priorities spans development, evaluation, and implementation of new drugs, diagnostics, and vaccines.
"Political commitment, regulatory cohesiveness, donor investments, and increased coordination among all stakeholders is necessary to make progress," says Professor Ali Zumla. "This includes upgrading of laboratory services for early and accurate diagnosis, development and validation of better diagnostic testing algorithms, effective treatment at points of care, and improved surveillance.
"This supplement also underlines preventable factors, such as crowded living conditions and under-nutrition that continue to make communities vulnerable to disease," continues Professor Zumla. "The influence of non-communicable diseases, such as smoking-related lung disease, diet-related diabetes mellitus, malnutrition, as well as alcohol and drug abuse, highlight the need for a multi-disciplinary approach in tackling both TB and HIV."
Despite increased funding for TB, several articles point to a serious shortfall which continues to persist. The financial difficulties faced by the Global Fund place recent gains in TB control and the numbers of HIV-infected persons on life-saving treatment at serious risk in many donor-reliant countries. The global fight against TB and HIV requires perseverance, assertiveness, and innovation, and clarity of intent well beyond current efforts. All authors in the supplement call on governmental, civil society, non-governmental groups, donors, and funders to work collectively to assist in global control of TB and, ultimately, its elimination.
###
Note to editors:
Contacts for press:
Professor Alimuddin Zumla, University College London Medical School, London United Kingdom
Telephone +44 (0) 7904638375
Email: a.zumla@ucl.ac.uk
Dr. Marco Schito, Henry M. Jackson Foundation for the Advancement of Military Medicine
Division of AIDS, NIAID, NIH, DHHS, Bethesda, Maryland, USA.
Telephone: +1-301-594-5374 Cell: +1(240) 421-8470
Email: schitom@niaid.nih.gov
'Tuberculosis: Local and Global' conference website and full programme of speakers: http://www.ucl.ac.uk/global-health/project-pages/symposia/tb-local-global
For full JID Supplement: see: Journal of Infectious Diseases website: http://jid.oxfordjournals.org/ after March 23rd.
Launch of the volume at World TB Day symposium:
The volume will be launched at a World TB Day symposium being held by UCL at the Royal Free Hospital campus on Friday March 23rd, 2012 (the day before world TB Day, March 24th 2012). The symposium will include presentations from the lead authors of the articles in this volume. A programme of the event is detailed below. The symposium has been organised by Dr Tim Mchugh, Dr Marc Lipman and Professor Ali Zumla.
Acknowledgements:
This JID supplement project has been funded in part with federal funds from the National Institute of Allergies and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, (contract HHSN272200800014C). Professor Ali Zumla receives support from EuropeAID, Belgium; European and Developing Countries Clinical Trials Partnership (EDCTP),Netherlands; UK Medical Research Council (MRC); and UBS OptimusFoundation, Switzerland, University College London Hospitals Comprehensive Biomedical Research Centre (UCLH-CBRC) and the UCL Hospitals National Health Service (NHS) Foundation Trust.
*Dr. Marco Schito's full affiliation is the Henry M. Jackson Foundation for the Advancement of Military Medicine [HJF], working under contract to the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, USA.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
[unable to retrieve full-text content]Hemorrhoids are a very serious condition that result many grown ups nowadays, in reality about one in every four adults living in the United States will develop hemorrhoids at some point in their existence. Perhaps the most ...
A soldier participating in a mutiny stands near civilians and burning tires lit in support of the mutiny, in Bamako, Mali Wednesday March 21, 2012. Gunshots could still be heard in the Malian capital late Wednesday, hours after angry troops started a mutiny at a military base near the presidential palace. Soldiers stormed the offices of the state broadcaster, yanking both TV and radio off the air.(AP Photo/Harouna Traore)
A soldier participating in a mutiny stands near civilians and burning tires lit in support of the mutiny, in Bamako, Mali Wednesday March 21, 2012. Gunshots could still be heard in the Malian capital late Wednesday, hours after angry troops started a mutiny at a military base near the presidential palace. Soldiers stormed the offices of the state broadcaster, yanking both TV and radio off the air.(AP Photo/Harouna Traore)
Civilians cheer as mutinous soldiers drive past in Bamako, Mali Wednesday March 21, 2012. Gunshots could still be heard in the Malian capital late Wednesday, hours after angry troops started a mutiny at a military base near the presidential palace. Soldiers stormed the offices of the state broadcaster, yanking both TV and radio off the air.(AP Photo/Harouna Traore)
Civilians walk past burning tires lit in support of mutinying soldiers, in Bamako, Mali Wednesday March 21, 2012. Gunshots could still be heard in the Malian capital late Wednesday, hours after angry troops started a mutiny at a military base near the presidential palace. Soldiers stormed the offices of the state broadcaster, yanking both TV and radio off the air.(AP Photo/Harouna Traore)
Civilians cheer as mutinous soldiers drive past, in front of a backdrop of burning tires, in Bamako, Mali Wednesday March 21, 2012. Gunshots could still be heard in the Malian capital late Wednesday, hours after angry troops started a mutiny at a military base near the presidential palace. Soldiers stormed the offices of the state broadcaster, yanking both TV and radio off the air.(AP Photo/Harouna Traore)
BAMAKO, Mali (AP) ? Soldiers stormed the presidential palace of one of the few established democracies in this corner of Africa and announced Thursday that they had seized control of the country, ousting Mali's president just one month before he was due to step down at the end of his legal term.
Gunfire could be heard ringing throughout the capital, and the mutinous soldiers imposed a nationwide curfew, warning people to stay off the streets until further notice. A flight headed to the capital of Bamako was forced to make a U-turn in the air after the airport closed.
The soldiers said they are overthrowing the government because of its mishandling of an ethnic Tuareg insurgency in the country's north that began in mid-January. The rebellion grew when fighters who had supported the late Libyan leader Moammar Gadhafi returned home heavily armed. The unrest has forced tens of thousands to flee, and has prompted fierce criticism of Mali's government.
Early Thursday, a group of around 20 soldiers in military fatigues were shown on national television crowding around a desk, facing the camera.
They announced that Mali is now under the control of the military's National Committee for the Reestablishment of Democracy and the Restoration of the State, or CNRDR. They said they were suspending Mali's constitution and dissolving its institutions.
The soldiers complained that the civilian government had not done enough to combat a rebellion by the ethnic Tuareg separatists, who want to carve out a homeland in the country's northern desert.
"The CNRDR representing all the elements of the armed forces, defensive forces and security forces has decided to assume its responsibilities and end the incompetent and disavowed regime of (President) Amadou Toumani Toure," they said, reading from a statement. "The objective of the CNRDR does not in any way aim to confiscate power, and we solemnly swear to return power to a democratically elected president as soon as national unity and territorial integrity are established."
The West African regional bloc ECOWAS said it "strongly condemns the misguided actions of the mutineers." The group said it was "all the more reprehensible, coming amidst the ongoing regional and international efforts to seek a peaceful solution to the rebellion in the north of the country."
The soldiers' declaration also came just hours after the presidential palace had rushed to deny that a coup was in progress, issuing a Tweet that said: "There is no coup in Mali. There's just a mutiny."
The latest developments mark a major setback for one of the region's few established democracies. The ousted president came to power himself in a 1991 coup, but was hailed for handing power to civilians. A decade later, he won the 2002 democratic election. The 63-year-old Toure was due to step down next month after two, five-year terms.
His whereabouts were unknown on Thursday. Contacted by telephone, a soldier at the palace said that the president's bodyguards had failed to fight the renegade soldiers, who burst in. They searched the grounds looking for him, but could not find Toure.
Young soldiers on motorcycles were shooting in the air Thursday morning in the capital of Bamako. Businesses remained shuttered and there was little traffic as most stayed home following the coup announcement.
On Wednesday, Defense Minister Gen. Sadio Gassama had come to a military camp in the capital for an official visit but failed to address the grievances of the rank-and-file soldiers in his speech to the troops. The rebellion has claimed the lives of numerous soldiers, and those sent to fight say they are not given sufficient supplies, including arms or food.
Recruits started firing into the air Wednesday morning and by afternoon, troops had surrounded the state television station, yanking both the television and radio signals off the air for the rest of the day. By Wednesday evening, troops had started rioting at a military garrison located in the northern town of Gao, some 2,000 miles (3,200 kilometers) away.
A freelance journalist from Sweden who was driving to her hotel near the TV station in Bamako around 4 p.m. Wednesday said that trucks full of soldiers had surrounded the state broadcaster, where they set up machine guns facing the building.
"They came and started setting up checkpoints. There were military in the streets, stopping people," said Katarina Hoije. "When we reached our hotel which is just in front of the TV station, there were lots of military outside, and more cars kept arriving ? pickup trucks with soldiers on them."
The Tuaregs, a traditionally nomadic people spread across the Sahara Desert, have risen up against the central government in Mali several times since the country's independence from France in 1960.
The newest rebellion launched in mid-January broke years of relative peace, and has been fueled by the return of Tuaregs from Libya who had fought in Gadhafi's army. Refugees have spilled over into four of the countries neighboring Mali due to the uprising.
Thousands of Tuaregs moved from Mali to Libya over the decades beginning in the 1970s, and many joined special divisions of Gadhafi's military where they earned higher salaries than in Mali. A relationship developed between the Tuareg and Gadhafi, who claimed they had distant blood links.
When the Gadhafi regime fell last year, Tuareg troops smuggled Gadhafi family members to neighboring Algeria and Niger. After Gadhafi was killed in his hometown of Sirte in October, many Tuaregs no longer felt safe in Libya and began returning to Mali.
The government has not disclosed how many government soldiers have been killed. The toll is believed to be significant and in February, military widows led a protest, publicly grilling Toure on television over his handling of the rebellion.
___
Associated Press writers Rukmini Callimachi and Michelle Faul in Dakar, Senegal, contributed to this report.
Instagram and Hipstamatic are getting together to let Hipstamatic users post to Instagram, according to Fast Company. It's the first time that Instagram's API has let anyone post to the photo-sharing network with anything but the official iPhone Instagram app. More »
http://www.findtoto.com/.. calls all your neighbors
http://thecenterforlostpets.com/
http://www.fidofinder.com/
re-print: Benedict Canyon Newsletter by Jan Marlyn Reesman The canyon is filled with ?LOST PET? signs. We all know many of these missing small dogs and cats may never show up again. The fate of ?the canyon?. However you should not stop searching. Cats have been found weeks after they go missing. Since the conception of the micro-chip, dogs have been returned home long after their replacement has arrived. When a pet goes missing it is vital to act fast and to never stop the search. Grab a powerful flashlight even during daylight hours, we learned this from watching ?CSI?. Search dark spaces. A frightened or injured cat will hide in dark spaces and will not come to you when called. An injured dog may also.
Immediately search your property thoroughly. Small dogs and cats can get into some incredibly strange places. Look in EVERY nook and cranny. Don?t assume that your pet would never crawl into a tiny space. Especially cats.. felines are a curious group. Look behind, under, and inside washing machines, clothes dryers, stoves, refrigerators, dishwashers, bookcases, behind water heaters, under furniture, under beds, in closets, in cabinets, in drain pipes, in sewer drains, in culvert pipes, under vehicles, under the hood of your car, in crawl spaces under the house, inside sheds and barns, etc. In the case of cats, also look in attic crawl spaces, on the roof, in roof gutters, and up in the trees.
Make some noise while you walk around the neighborhood! Animals can hear you from great distances. If your pet has a favorite ?squeaky toy? bring it along and use it to help you make familiar noises. It?s also important to stop regularly, be quiet, and listen for your pet to make a noise in reply. Especially at dawn and dusk.
Place strong-scented articles outside your home to attract your pet. Leaving the pets bed, a piece of your clothes or personal blanket. They will help to give the pet an anchor to stay near or on if he or she is lost when you are away from home or if you have to leave the last area where you saw your pet.
Put flyers everywhere. It is extremely important to post MANY flyers within at least a 1-mile radius of where it was lost. DO NOT PUT YOUR NAME OR ADDRESS ON YOUR FLYER! List the date and place your pet was lost, breed of dog or cat, sex, age, weight, color, markings, and your telephone number. Offer a reward, but don?t state the amount. It is very important to always withhold several identifying marks and characteristics of your lost pet. Beware of the scammer. Post the flyers at waist level on telephone poles and at eye level in such places as veterinary offices, pet shops, beauty shops, grocery stores, community bulletin boards, churches, pizza parlors, convenience stores, near schools, and on school bulletin boards, on windshields, in mailboxes, fire stations, Starbucks, food trucks and construction worksites. Examine your posted flyers frequently and replace the ones that are missing or damaged.
Walk the neighborhood and talk to everybody. Go to each house in the area where your pet was lost and talk to the residents; give them your flyer. If no one is home, leave the flyer attached to his or her door, don?t forget to bring tape. Talk to everybody you run across ie, neighborhood children and parents waiting at the school bus stop. This also includes the paperboys, school crossing guards, neighborhood crime watch groups, garbage pick-up crews, postal workers, sanitation workers, construction workers, etc. Give them your flyer. Place an ad in your local newspaper. Some will do this for free. Be sure to advertise in the Sunday edition as well as during the week. Also place an ad in any ?Penny Saver? type of publications. Check the newspaper ?found? ads every day. Also check online ?Lost and Found?. Most newspapers provide free ads to people who have found lost pets.
Call local veterinarian offices during the day. After 5 PM, call veterinarian emergency clinics. If an office has taken in or treated any animal that even remotely resembles your pet, VISIT THE OFFICE IN PERSON. Your description of your pet and their description of the same pet rarely match. YOU MUST GO SEE FOR YOURSELF!
Get phone numbers of local rescue organizations. The free Pet Press (at the library and pets stores) has current lists. Call each of the rescue organizations and ask for their help and find out if they have your pet. These groups generally network with each other and will pass the word about your case. VISIT your local Animal Control, humane societies, and animal shelters, including the ones in surrounding areas. You must actually visit the animal control and humane shelters every day or two. It works well if several family members can take turns visiting the shelters. Be sure to check all areas of the shelter, including the infirmary. Also be aware that dogs may be housed in the cat section and vice-versa.
Leave a picture of your pet and your phone number at each shelter, befriend them. Find out the holding period of each animal control and humane shelter. Be aware of how much time you have to claim your pet before it is euthanized!
Check shelters out of your area in person and online. A Good Samaritan may have taken your pet in only to have it escape a week or more later.
Don?t ever give up! Pets have been known to find their way back home after being lost for several months.
PREVENTION: Get your pet Micro-chipped, keep tags current.
Keep pet tags current and check that they are still in place and legible. A good idea is to write your phone number directly onto the collar. I do not remove my dog?s collar even when she is being bathed. I have heard the excuse that the lost pet was not wearing a collar and id because they were just bathed.
Your tag should have more then one phone number, your home number, cell, your vet etc.. I keep two collars and tags on my dogs as well as a microchip.
Get an ?Acme Dog Whistle?. Blow the whistle whenever you feed or give treats to your pet. Leave the whistle next to the treats so that you will remember to use it, this really works. The high-pitched sound from these whistles can carry up to a mile or more. Cats are attracted to this sound as well as dogs. (It is also a great way to teach a pet the ?come command?.)
Keep fence gates closed securely. Self closing gates area good idea. Always transport a cat in a carrier. Never take your cat to the Vet or anywhere else unless it is secured. A hand carried cat can bolt and hide if frightened by loud noises. When a cat is frightened in strange surroundings, especially with traffic noise around, it will hide and will not come to you.
If you have a dog who is an escape artist, try leaving a piece of broken leash hanging front their collar so that it will appear that the dog broken lose as opposed to being out for a walk.
NEVER, NEVER leave a choke collar on a dog when it is not attached to a leash. It will eventually become a HANGMAN?S NOOSE!
Have current photos of your pet.
A pillowcase is a quick way to transport cats or injured small animal. As a final point, spay or neuter your pets! Both males and females will be much less likely to wander if ?fixed.? One of many online resources: http://www.laanimalservices.com/LostServices.htm
Jan Marlyn Reesman was a licensed heath technician and animal behaviorist. Partial name-dropping client list: Whoopi Golberg, Calvin Klein, Billy Crystal, James Caan, Dyane Cannon, Barry Diller, Sandy Gallin, Gabe Kaplan, Frank Wells, Barbara Benedek, Frank Mariani, Richard Dreyfuss, Hal Linden, Jack Warner Estate dogs and John Ritter.
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This entry was posted on Tuesday, March 20th, 2012 at 8:51 am and is filed under blog, cat behavior, safety. You can follow responses to this entry through the Comments RSS Feed. Both comments and pings are currently closed.
: Account Exec ? Business Sales : Verizon Wireless : Bellevue : Washington : US : Tuesday, March 20, 2012 10:48:59 GMT : Active
Verizon Wireless, is at present in need of Account Exec ? Business Sales at Tuesday, March 20, 2012 10:48:59 GMT. This job located in Bellevue, WA, and published 13 hours ago.
Good news, it still active, so besure to read the job description below and go ahead hit the View/Apply button to proceed further.
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Account Exec ? Business Sales Job Descriptions/Requirements provided by Verizon Wireless. Click the ?View Complete Job Description? link at the bottom of this description to view the complete job description.
Responsibilities Performance excellence that s Verizon Wireless. We re committed to doing and being the best, and we ve worked hard to build a foundation of?
View Complete Job Description ?
MAP OF JOB LOCATION
Zoom & Street View. Zoom in to get a closer view of the job?s place and do a Street View, to give your self a lil bit of a glance of the where about of job before going there, via 360-degree street-level imagery. Click here to learn how.
Get Directions. Turn by turn lines leading to the job?s place, just one click of a button away. Here?s how :
Directions from your location ?- to the job location .
How to do A Street View
As in Google Maps, Street View lets you explore places through 360-degree street-level imagery. In Lexxio, this feature should help you looking at the job location and check it out just before going there.
1. Zoom in
First, Zoom in, by clicking on the job location marker. This will get you to the street level zoom.
At this zoom level you will see the road/street?s name nearby the marker. This is your first hint of the job location whereabouts.
2. Drag and Drop Pegman
Drag Pegman?????to any positions at the closest road to the marker. Roads with Street View imagery will appear with a blue border.
Notice the green shade with dotted border under Pegman, it means it still finding the best possible position to land the Pegman. The shade will become solid green when it finds the right position. That?s when you release your mouse drag, and drop it. You should see the street view of the job location at that exact time.
3. Navigating In Street View
Rotate
? use the wheel in the control panel in the top left corner. ? or use the left and right arrows on your keyboard ? or click and drag with your mouse.
Walk
? click on one of the white arrows overlaid on the street. ? or use the up and down arrows on your keyboard.
Tips: Use both Rotate and Walk navigation, to locate and get to closest position of the marker, as that?s where the job location is. You should also see an address at the top of the map. This address is approximate, based on latitude and longitude position provided by the job poster. It might be usefull to take a note on this address, just incase you can?t find any physical address of the job location at the apply page.
Exit
? click Exit cross on the top right corner of the Street View map.
Thassit. That?s all there is about Street View. You?re ready to get the fun begin, and enjoy a bit of a view and situation of the job location you?re about to apply to.
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Public release date: 22-Mar-2012
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